The Cutting Edge
April 2005

Infliximab for the Treatment of Adult-Onset Pityriasis Rubra Pilaris

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Copyright 2005 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2005

Arch Dermatol. 2005;141(4):423-425. doi:10.1001/archderm.141.4.423

A 77-year-old man presented in June 2002 with a 2-month history of a progressive eruption that initially involved his scalp and progressed to his face, neck, trunk, and extremities. This eruption was associated with chills. His medical history was remarkable for congestive heart failure, hypertension, a mitral valve repair, and gout. His medications included warfarin sodium, digoxin, losartan potassium, hydrochlorothiazide, and terazosin hydrochloride. He had also been taking prednisone and cephalexin prescribed by his primary care physician for his skin condition. Physical examination revealed erythematous, scaly plaques and papules on his scalp, face, neck, upper trunk, and proximal extremities (Figure 1). He had ectropion of both lower eyelids, keratoderma of the palms and soles, and significant pitting edema of the lower extremities. A biopsy specimen was obtained and revealed parakeratosis, moderate acanthosis, and a mild superficial perivascular lymphocytic infiltrate, consistent with pityriasis rubra pilaris (PRP).

Figure 1.
Image not available

Case 1: note diffuse erythema and scaling.

Initial therapy consisted of acitretin, 25 mg twice daily, topical 0.1% triamcinolone acetonide ointment, and oral antihistamines. Prednisone therapy was tapered, and cephalexin therapy was discontinued. The patient was admitted to the hospital for intensive therapy with twice-daily whirlpool baths and to monitor his hemodynamic status. Lower extremity edema improved with hospitalization. His skin eruption improved only slightly. Acitretin therapy was continued as an outpatient; however, the skin eruption failed to improve. After 4 months of acitretin monotherapy, cyclosporine A was added at a daily dose of 3 mg/kg in October 2002. After 2 months of the combination therapy of acitretin with cyclosporine A, the patient's skin eruption worsened, with increased total body skin area involvement and increased pruritus.


A 53-year-old man presented in November 2003 with a 6-month history of pruritic lesions that initially involved his left shoulder, then spread to involve his chest and face and subsequently his trunk and legs. He complained of chills. Physical examination revealed erythematous, scaly patches and plaques that involved approximately 99% of his skin surface. Several 1- to 1.5-cm “islands of sparing” were present. He had keratoderma of the palms and soles as well. His medical history was remarkable for hypertension. His family history was significant for a brother with PRP who responded to treatment with acitretin monotherapy. His medications included lisinopril, aspirin, and hydroxyzine hydrochloride. He had been using tacrolimus ointment, which was prescribed by his primary care physician for the skin eruption. A biopsy specimen was obtained and revealed parakeratosis, acanthosis, and focal follicular plugging, consistent with PRP.

Initial therapy consisted of acitretin, 50 mg once daily, emollients, and oral antihistamines. After 2 months of this therapy, the patient had some improvement of his palms and soles only. The rest of his eruption failed to improve.


Pityriasis rubra pilaris is an uncommon, idiopathic, papulosquamous disorder that often progresses to erythroderma and causes a disabling keratoderma. No single therapy is universally effective, and some cases are resistant to multiple therapies. Systemic retinoids,13 methotrexate,3,4 immunosuppressive agents (azathioprine and cyclosporine A),5,6 and phototherapy3,79 have been used with variable success.


In case 1, the patient was admitted to the hospital again in December 2002. He was given infliximab at a dose of 5 mg/kg. Therapy with cyclosporine A was discontinued; acitretin therapy was maintained at a dose of 25 mg twice daily. Two weeks after infliximab was administered, the patient had marked improvement of his skin disease, with decreased erythema, pruritus, and total body skin area involvement (Figure 2). Given the response to infliximab, the patient received 4 subsequent doses of infliximab at weeks 4, 8, 14, and 22 after the initial dose with continuing improvement. The dose of acitretin was tapered as well without flare of the skin lesions. The patient remains 98% clear 1 year after the first infliximab dose. He is presently taking acitretin, 25 mg 3 times weekly.

Figure 2.
Image not available

Case 1: erythema and scaling subsided following infliximab therapy.

In case 2, infliximab was administered at a dose of 5 mg/kg, and a subsequent dose of 5 mg/kg was administered 2 weeks later. The patient was also maintained on acitretin therapy. Two weeks after the first dose of infliximab, the patient had markedly less erythema, pruritus, and desquamation. Overall, he showed a 50% improvement after the infliximab infusion. He is presently taking acitretin, 50 mg once daily.


Therapy for PRP is largely based on anecdotal reports owing to the rarity of cases, lack of controlled trials, and the idiopathic nature of the disorder. In addition, some cases of PRP spontaneously resolve without therapy, and so evaluation of the success of any therapy is problematic. Multiple therapies have been tried: high-dose vitamin A (retinol),1,2 synthetic retinoids,3,4 methotrexate,3,4 azathioprine,5 cyclosporine A,3,6 stanozolol,10 phototherapy,3,79 and extracorporeal photochemotherapy.11

Systemic retinoids and methotrexate are the most frequently used therapies for PRP. Another more common papulosquamous disorder, plaque psoriasis, responds to these agents as well. Given the clinical overlap and therapeutic response overlap between psoriasis and PRP, and given recent evidence that infliximab is efficacious in treating psoriasis,12,13 we decided to administer infliximab to our patients with PRP.The response in both patients was rapid and significant. It is highly likely that infliximab was responsible for the clinical response in the 2 patients.

Infliximab is a chimeric monoclonal antibody that binds to the proinflammatory cytokine tumor necrosis factor α. Initially developed for the treatment of Crohn disease, this medication has been reported to be effective in treating a number of inflammatory dermatoses in addition to psoriasis, including hidradenitis suppurativa,14 pyoderma gangrenosum,15 and cutaneous sarcoidosis,16 among others.

With the excellent responses our patients had to infliximab, we hypothesize that tumor necrosis factor α may play a pathophysiological role in PRP. Controlled studies with tumor necrosis factor α inhibitors (infliximab, etanercept, adalimumab, and thalidomide) for PRP would be informative. In conclusion, we recommend infliximab as an alternative agent for treating adult-onset PRP.

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Article Information

Correspondence: Diya F. Mutasim, MD, Department of Dermatology, University of Cincinnati, PO Box 670592, Cincinnati, OH 45267-0592 (

Accepted for Publication: June 30, 2004.

Financial Disclosure: None.


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Winkelmann  RKThomas  JR  IIIRandle  HW Further experience with toxic vitamin A therapy in pityriasis rubra pilaris Cutis 1983;31621- 632
Randle  HWDiaz-Perez  JLWinkelmann  RK Toxic doses of vitamin A for pityriasis rubra pilaris Arch Dermatol 1980;116888- 892
Dicken  CH Treatment of classic pityriasis rubra pilaris J Am Acad Dermatol 1994;31997- 999
Clayton  BDJorizzo  JLHitchcock  MG  et al.  Adult pityriasis rubra pilaris: a 10-year case series J Am Acad Dermatol 1997;36959- 964
Hunter  GAForbes  IJ Treatment of pityriasis rubra pilaris with azathioprine Br J Dermatol 1972;8742- 45
Usuki  KSekiyama  MShimada  TShimada  SKanzaki  T Three cases of pityriasis rubra pilaris successfully treated with cyclosporin A Dermatology 2000;200324- 327
Herbst  RAVogelbruch  MEhnis  AKiehl  PKapp  AWeiss  J Combined ultraviolet A1 radiation and acitretin therapy as a treatment option for pityriasis rubra pilaris Br J Dermatol 2000;142574- 575
Kirby  BWatson  R Pityriasis rubra pilaris treated with acitretin and narrow-band ultraviolet B (Re-TL-01) Br J Dermatol 2000;142376- 377
Yaniv  RBarzilai  ATrau  H Pityriasis rubra pilaris exacerbated by ultraviolet B phototherapy [letter] Dermatology 1994;189313
Pavlidakey  GPHashimoto  KSavoy  LBHeller  GLIacobelli  DBarfield  L Stanozolol in the treatment of pityriasis rubra pilaris Arch Dermatol 1985;121546- 548
Hofer  AMullegger  RKerl  HWolf  P Extracorporeal photochemotherapy for the treatment of erythrodermic pityriasis rubra pilaris Arch Dermatol 1999;135475- 476
Oh  CJDas  KMGottlieb  AB Treatment with anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody dramatically decreases the clinical activity of psoriasis lesions J Am Acad Dermatol 2000;42829- 830
Chaudhari  URomano  PMulcahy  LDDooley  LTBaker  DGGottlieb  AB Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial Lancet 2001;3571842- 1847
Martinez  FNos  PBenlloch  SPonce  J Hidradenitis suppurativa and Crohn's disease: response to treatment with infliximab Inflamm Bowel Dis 2001;7323- 326
Tan  MHGordon  MLebwohl  OGeorge  JLebwohl  MG Improvement of Pyoderma gangrenosum and psoriasis associated with Crohn disease with anti-tumor necrosis factor alpha monoclonal antibody Arch Dermatol 2001;137930- 933
Mallbris  LLjungberg  AHedblad  MALarsson  PStahle-Backdahl  M Progressive cutaneous sarcoidosis responding to anti-tumor necrosis factor-alpha therapy J Am Acad Dermatol 2003;48290- 293