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The Best of the Best
October 2010

Top-Accessed Article: Photoaging and Chronological Skin Aging

Author Affiliations

Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2010

Arch Dermatol. 2010;146(10):1124. doi:10.1001/archdermatol.2010.214

Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, Voorhees JJ. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462-1470.

This review article summarizes how UV radiation reduces the procollagen synthesis and makes the collagen fibril disorganized in the human skin. Also, the authors explain the roles of the partially degraded collagen fragments and the resultant reduced mechanical tension on fibroblasts in the basal procollagen synthesis in photoaged and chronologically aged skin, as well as how retinoids repair and prevent skin aging. In today's world, every woman and man, regardless of age, is interested in maintaining young and healthy skin. To develop truly effective cosmeceutical products and anti–skin-aging drugs, an understanding of the molecular mechanism of skin aging and photoaging is essential; this is provided very nicely by this article.

From June 2004 through August 2009, this article was viewed 3070 times on the Archives of Dermatology Web site.

Contact Dr Chung at the Department of Dermatology, Seoul National University College of Medicine, Seoul 110-744, Korea (