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January 17, 2011

Top-Accessed Article: Keratosis Pilaris Rubra

Author Affiliations

Author Affiliations: Department of Pediatric Dermatology, Henry Ford Hospital, Detroit, Michigan.


Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2011

Arch Dermatol. 2011;147(1):20. doi:10.1001/archdermatol.2010.353

Marqueling AL, Gilliam AE, Prendiville J, Zvulunov A, Antaya RJ, Sugarman J, Pang ML, Lee P, Eichenfield L, Metz B, Goldberg GN, Phillips RJ, Frieden IJ. Keratosis pilaris rubra: a common but underrecognized condition. Arch Dermatol.2006;142(12): 1611-1616.

This excellent article by Marqueling and colleagues described 27 patients with widespread erythematous keratotic follicular eruptions termed keratosis pilaris (KP) rubra (KPR). The authors reported how common KPR is and suggested 2 modes of heredity (autosomal dominant in standard KP and X-linked in the rubra form). They reassured us that KPR is not associated with any systemic conditions. Unlike KP, the incidence of KPR increases with age.

The authors differentiate KP, KPR, KP atrophicans, and erythromelanosis faciei et colli. It might be argued that they are all KP with variants, similar to the 10 types of lichen planus. No treatment options showed uniform effective therapy. Does that mean that we do not try them? Of course we do, but now we have a sober appraisal of what to expect.

From June 2004 through August 2009, this article was viewed 2807 times on the Archives of Dermatology Web site.

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Contact Dr Shwayder at the Department of Pediatric Dermatology, Henry Ford Hospital, 3031 W Grand Blvd, Ste 800, Detroit, MI 48202 (