Pachydermodactyly is a rare, benign, acquired form of digital fibromatosis. The etiology of pachydermodactyly is unknown but is believed to be due to repeated mechanical injury of the skin. Sagransky and coauthors report 2 cases of pachydermodactyly identified in poultry processing workers and review other conditions associated with these cutaneous findings.
The autoimmune target of diffuse alopecia areata may be the melanin pigment system and/or melanocytes. Kaminska and coauthors report a case of diffuse alopecia areata with regrowth of white hair and loss of skin pigment and perform a histopathologic examination on epidermal and follicular specimens.
Samrao and coauthors investigated the preliminary safety and efficacy of apremilast, an oral phosphodiesterase 4 inhibitor for atopic dermatitis.
Pandya et al determine the efficacy and safety of deferasirox in a pilot trial for the treatment of patients with porphyria cutanea tarda (PCT). In a 6-month study, 10 patients with PCT were treated with 250 mg/d of deferasirox, with an increase to 500 mg/d after 2 months if new blisters continued to develop.
To explore the frequency of excisions and yields of histopathologically confirmed skin cancer, Waldmann and coauthors assessed a population-based skin cancer screening intervention in the German state of Schleswig-Holstein from July 1, 2003, to June 30, 2004.
To identify whether there is a relationship between solar elastosis and the development of wrinkles in human skin, Tsukahara and colleagues measured wrinkle depth on the forehead and lateral canthus of 58 human cadavers using image analysis. The relationship between elastosis ratios and wrinkle depths was investigated.
The role of physical activity in the risk of psoriasis remains unknown, although activity may affect psoriasis risk through effects on systemic inflammatory mediators. Frankel et al evaluate the possible association in a group of participants with psoriasis from the Nurses’ Health Study II.
Leonardi-Bee and coauthors conducted a systematic review and meta-analysis of 25 studies to determine the association between smoking and nonmelanoma skin cancer—specifically, basal cell carcinoma and cutaneous squamous cell carcinoma.