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Editor's Correspondence
Nov/Dec 15, 2010

Multidose of Restylane for Facial Augmentation—Reply

Author Affiliations

Author Affiliation: Department of Otolaryngology–Head and Neck Surgery, Dalhousie University, Queen Elizabeth 2 Health Science Centre, Halifax, Nova Scotia, Canada.

Arch Facial Plast Surg. 2010;12(6):433-434. doi:10.1001/archfacial.2010.77

In reply

I appreciate the comments made by Dr Emilson and colleagues with regard to our Research Letter on the use of multidose Restylane for facial augmentation. Dr Emilson does question whether the inoculum of Staphylococcus epidermidis meets the standard for an appropriate microbiologic challenge. We did report that we seeded 2 vials of Restylane with 102 and 105 colony-forming units (CFUs)/mL, respectively. Unfortunately, during our revisions, the actual inoculum used in the microbiology laboratory was lost in translation. This should have been reported to be 102 and 105 CFUs/mL. This small but relatively important typographical error was not detected by me during the revision process, and I take full responsibility for this. The method of inoculation and culture technique was supervised by a microbiologist at our institution, a large tertiary care center in Atlantic Canada.

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