Author Affiliation: Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona.
Prevention of type 2 diabetes mellitus (T2DM) has been studied in several randomized clinical trials1- 6 in adults at high risk of developing diabetes. Most enrolled only persons with impaired glucose tolerance (IGT) during an oral glucose tolerance test (OGTT). Other high-risk characteristics often included obesity and elevated fasting plasma glucose (FPG) level. All these studies had OGTT-diagnosed diabetes as the primary outcome, although exact definitions differed among studies.
Knowler WC. Prevention of Type 2 DiabetesComment on “Lifestyle Modification and Prevention of Type 2 Diabetes in Overweight Japanese With Impaired Fasting Glucose Levels”. Arch Intern Med. 2011;171(15):1361-1362. doi:10.1001/archinternmed.2011.367