An estimated 60 million Americans use nonsteroidal anti-inflammatory drugs (NSAIDs) regularly. The study by Cho et al uses prospective data from 2 different cohorts to estimate the risk of renal cell carcinoma related to NSAID use and reports a pooled multivariate relative risk of 1.51 (95% confidence interval, 1.12-2.04) for nonaspirin NSAID use, with a dose-response relationship based on duration of use. Although the absolute risk differences between users and nonusers of NSAIDS were quite low, we find the results compelling in light of the widespread use of these drugs.
Johansen KL. Renal Cell Carcinoma and the Widespread Use of NSAIDs Comment on “Prospective Evaluation of Analgesic Use and Risk of Renal Cell Cancer”. Arch Intern Med. 2011;171(16):1493. doi:10.1001/archinternmed.2011.375