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Editor's Correspondence
Dec 12 2011

Soy Isoflavone Supplementation in Menopausal Women—Reply

Author Affiliations

Author Affiliations: Geriatric Research, Education, and Clinical Center, Miami Veterans Affairs Healthcare System, and Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida (Dr Levis); Department of Pediatrics, University of South Florida, Tampa (Ms Xu and Dr Krischer); and National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas (Dr Doerge).

Arch Intern Med. 2011;171(22):2067-2068. doi:10.1001/archinternmed.2011.583

In reply

A total of 66 randomized participants did not complete the study (23 in the soy isoflavone group and 43 in the placebo group).1 A comparable number of women in each group reported moving out of state, having a sick family member, a new job, or a desire to eat soy products as the reason to discontinue their participation. Although there was a marked difference in the proportion of participants who were no longer interested in participating in the study or were lost to follow-up (16 [19%] in the soy isoflavone group and 30 [34%] in the placebo group), we did not find any objective measures that could explain this difference.

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