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In their large meta-analysis including 11 randomized controlled trials for a total of more than 65 000 patients, Ray et al1 failed to find evidence for the benefit of statin therapy on all-cause mortality in the setting of high-risk primary prevention.
Findings of this meta-analysis are consistent with the results of a previous meta-analysis that included individuals without clinically manifest coronary heart disease.2 Furthermore, their methodology is accurate, and the authors obtained relevant unpublished data from the authors of original studies. Thus, their results appear to be reliable questioning the role of statins in primary prevention.
Dentali F, Guasti L. Are Statins Effective in High-Risk Primary Prevention?. Arch Intern Med. 2010;170(22):2042-2044. doi:10.1001/archinternmed.2010.458