We read with interest the article by Lee et al,1 who conducted a case-case-control study to evaluate risk factors for fungemia caused by fluconazole-resistant Candida glabrata. The authors identified previous fluconazole use (and linezolid use) as a significant risk factor for fluconazole-resistant C glabrata fungemia, whereas cefepime and metronidazole use were independent risk factors for fluconazole-susceptible C glabrata fungemia.
Tumbarello M, Posteraro B, Trecarichi EM, Sanguinetti M. Fluconazole Use as an Important Risk Factor in the Emergence of Fluconazole-Resistant Candida glabrata Fungemia. Arch Intern Med. 2009;169(15):1444-1445. doi:10.1001/archinternmed.2009.243