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Editor's Correspondence
November 23, 2009

A Question of the Clinical Relevance of Determining Thrombomodulin Level While Receiving Anticoagulant Therapy

Author Affiliations

Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2009

Arch Intern Med. 2009;169(21):2031. doi:10.1001/archinternmed.2009.422

We would like to thank Lind et al1 for their study on thrombomodulin as a marker for bleeding complications during warfarin treatment. This longitudinal cohort study demonstrates that patients who have high levels of soluble thrombomodulin (sTM) and are receiving long-term vitamin K antagonist therapy appear to be at higher risk of clinically relevant and major bleeding complications. If validated, such a laboratory test would be of great importance and clinical utility in assessing the risk of long-term vitamin K antagonist therapy.

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