Author Affiliations: Brooke Army Medical Center, Fort Sam Houston, Texas (Dr Viswanathan); and Endocrinology Service, Walter Reed National Military Medical Center, Bethesda, Maryland (Dr Vigersky).
Nonprescription drugs such as PC-SPES (Botanic Lab) (PC, abbreviation for prostate cancer; SPES, Latin for hope)—an herbal therapy for prostate cancer—are part of the complementary and alternative medicine (CAM) approach to health. PC-SPES was removed from the US market in 2002 owing to contamination with indomethacin, diethylstilbestrol, and warfarin.1 Yet it and similar preparations remain widely used because they are available online. Their clinical effect on nonprostatic, hormonally responsive systems has not been studied.
Viswanathan L, Vigersky RA. The Effect of Herbal Medications on Thyroid Hormone Economy and Estrogen-Sensitive Hepatic Proteins in a Patient With Prostate Cancer. Arch Intern Med. 2012;172(1):58-60. doi:10.1001/archinternmed.2011.596