In their excellent article, Dagogo-Jack and Santiago1 include a helpful listing (Table 3) of wholesale prices of currently used oral hypoglycemic agents. Information comparing medications in terms of effectiveness and price is of great importance to patients, physicians, and payors when choosing between similar drugs within a pharmacological class or considering the benefits of combination therapy. However, the cost of troglitazone (Rezulin) was not included in this table. The wholesale cost to the pharmacist (at my medical center) for a 30-day supply of the lowest possible dose of this drug is $104.40, making it 2- to 72-fold more expensive than any of the other listed medications. Pathophysiological rationale aside, I think this is important information for readers when assessing the relative merits of these drugs.
Bachman KH. Cost of Troglitazone Therapy. Arch Intern Med. 1998;158(9):1038. doi: