Author Affiliations: Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India (Dr Andrade); and Department of Psychiatry, Creighton University School of Medicine, Omaha, Nebraska (Dr Fernandes).
In a small (n = 53), 12-month, randomized controlled trial, Hajjar et al1 found that elderly hypertensive subjects with impaired executive functioning showed greater executive improvements with candesartan (an angiotensin receptor blocker [ARB]) therapy than with lisinopril or hydrochlorothiazide. They concluded that cognitive protection may arise through selectivity of angiotensin receptor blockade with ARBs.
Andrade C, Fernandes P. Do Angiotensin Receptor Blockers Really Hold Promise for the Improvement of Cognitive Functioning?. Arch Intern Med. 2012;172(15):1191-1192. doi:10.1001/archinternmed.2012.2091