Author Affiliations: Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India (Dr Andrade); and Department of Psychiatry, Creighton University School of Medicine, Omaha, Nebraska (Dr Fernandes).
Van der Ploeg et al1 analyzed prospectively collected data from a large population-based cohort and found that, regardless of age, sex, body mass index, self-rated health, level of physical activity, baseline cardiovascular disease and diabetes, and other confounders, longer hours of sitting were dose-dependently associated with greater risk of all-cause mortality across an average of 2.8 years of follow-up. They described mechanisms and cited previous literature to support a hypothesis that excessive sitting, independent of physical activity, is harmful to health.
Andrade C, Fernandes P. Is Sitting Harmful to Health? It Is Too Early to Say. Arch Intern Med. 2012;172(16):1272-1273. doi:10.1001/archinternmed.2012.2539