Author Affiliations: Health Screening Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea (Dr Kwak); and Carcinogenesis Branch, Family Medicine Clinic, and Center for Cancer Prevention and Detection, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea (Dr Myung).
We appreciate the letter of DiNicolantonio et al in response to our report1 in the Archives. We acknowledge that several methodologic issues raised by DiNicolantonio et al are important for our main conclusions.
First, regarding the small sample size and short follow-up period, we stated in the limitations of the “Comment” section1(p693) that
Kwak SM, Myung S. The Big Ones That Got Away: Omega-3 Meta-analysis Flawed by Excluding the Biggest Fish Oil Trials—Reply. Arch Intern Med. 2012;172(18):1427-1428. doi:10.1001/archinternmed.2012.4300