Author Affiliations: Dr Carlton, Emergency Department (Dr Carlton) and Department Of Cardiology (Dr Greaves), Poole Hospital, Dorset, England; and Department of Cardiology, John Radcliffe Hospital, Oxford, England (Dr Gamble).
We would like to commend Reichlin et al1 for their novel algorithm for the rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. This study gives promise to the development of clinically relevant rapid assessment strategies, which will be vital in reducing emergency department (ED) overcrowding, patient inconvenience, and associated health care costs.2 However, this study raises some unanswered questions in the development of early diagnostic strategies using sensitive troponin assays.
Carlton EW, Gamble JHP, Greaves K. Testing Times: We Are Still Some Way From Getting the Best Out of Sensitive Troponin Assays. JAMA Intern Med. 2013;173(6):477-478. doi:10.1001/jamainternmed.2013.2273