Author Affiliations: Department of Health Science, University of Milano-Bicocca and Geriatric Clinic, S. Gerardo Hospital, Monza, Italy (Dr Bellelli); Geriatric Research Group, Brescia, Italy (Drs Bellelli, Morandi, and Trabucchi); Rehabilitation and Aged Care, “Ancelle della Carità” Hospital, Cremona, Italy (Dr Morandi); and University Tor Vergata, Rome, Italy (Dr Trabucchi).
We read with interest the Invited Commentary by Vasilevskis and Ely1 entitled “The Danger of Delirium” on the article by Gross and colleagues2 evaluating delirium and long-term cognitive trajectories in patients with dementia. We agree with the authors' indication on the need to preserve the “functional integrity of the brain,” and we want to highlight the importance to identify the most appropriate means to reach this objective, since we still currently lack information on the pathological basis explaining the negative long-term effects of delirium.
Bellelli G, Morandi A, Trabucchi M. The Meaning of Delirium. JAMA Intern Med. 2013;173(7):597-599. doi:10.1001/jamainternmed.2013.3293