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Editor's Correspondence
May 13, 2013

Smoking Bans Research—Reply

Author Affiliations

Author Affiliations: Nicotine Dependence Center Research Program (Drs Hurt and Ebbert), Department of Health Sciences Research (Dr Roger), and Division of Cardiovascular Diseases in the Department of Internal Medicine (Dr Roger), Mayo Clinic, Rochester, Minnesota.

JAMA Intern Med. 2013;173(9):836-837. doi:10.1001/jamainternmed.2013.928

In reply

We agree that observational studies are vulnerable to confounding. However, one can hardly expect a randomized clinical trial on secondhand smoke. Rigorous observational studies are the only design that can be used. Regarding the article by Ioannidis,1 the editors of PloS Med,2 in their editorial about that article, state that “He stresses that reliable evidence generally comes from several studies and from several teams of researchers, and that what matters is the totality of the evidence.”

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