Author Affiliations: Department of Intensive Care Medicine, VU Medical Centre (Dr Tuinman), and Department of Intensive Care Medicine, Academic Medical Centre (Drs Muller and Juffermans), Amsterdam, the Netherlands.
We read with interest the meta-analysis of Chatterjee and colleagues,1 which reports higher rates of mortality and myocardial reinfarction in patients with myocardial infarction (MI) receiving a blood transfusion. These findings can be added to previous evidence for a restrictive transfusion policy in critically ill patients. As a possible mechanism for the association between transfusion and reinfarction in their meta-analysis, the authors suggest triggering of platelet aggregation by red blood cell transfusion.2
Tuinman PR, Muller MC, Juffermans NP. Transfusion in Myocardial Infarction: Bloodcurdling?. JAMA Intern Med. 2013;173(12):1156-1157. doi:10.1001/jamainternmed.2013.6515