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In Reply We completely agree with Dr Keller about the importance of having aspirin intake dose information and his comment about what we reported was “time dose” or use duration-dose pattern but not quantitative dose of aspirin intake. If an intake dose-response pattern were found with the aspirin dose data, this would strengthen the evidence supporting an association between aspirin use and age-related macular degeneration (AMD) and inform clinical practice. However, we do not have precise dosage data collected from our study sample.
Wang JJ, Liew G, Mitchell P. Is 81-mg Aspirin Associated With Age-Related Macular Degeneration Risk?—Reply. JAMA Intern Med. 2013;173(15):1476-1477. doi:10.1001/jamainternmed.2013.8131