IN THE IDEAL WORLD, the practice of medicine would be entirely evidence based, with decisions on how to use new medications being based on well-designed, double-blind, placebo-controlled studies. One need not look further than the multibillion dollar nutritional-supplement and "natural-treatments" market to know that a considerable amount of "medical products" are consumed without a good scientific basis. The use of parenteral phenytoin, particularly in regard to fosphenytoin sodium, however, is based on good, sound scientific principles.
Labiner DM. Data vs Opinion, Phenytoin vs FosphenytoinThe Saga Continues. Arch Intern Med. 1999;159(22):2631-2632. doi:10-1001/pubs.Arch Intern Med.-ISSN-0003-9926-159-22-ied90008