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In 1772, Heberden first reported his personal experience of angina pectoris as a retrosternal pain characterized by a crushing, burning, or squeezing sensation.1 Decades of later work by a host of other scientists uncovered angina as a cardinal manifestation of myocardial ischemia, although the biology underlying the manifestation of angina remains poorly understood.2 Perception of anginal symptoms is an important survival mechanism in patients with acute coronary syndrome (ACS), alerting the need for urgent medical care.
Akinkuolie AO, Mora S. Are There Sex Differences in Acute Coronary Syndrome Presentation?A Guide Through the Maze. JAMA Intern Med. 2013;173(20):1861-1862. doi:10.1001/jamainternmed.2013.8075