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Long-term follow-up of randomized trials has demonstrated that incidental exposure of the heart during radiotherapy for breast cancer can increase the subsequent risk of heart disease.1 Radiation-related increases in heart disease risk have subsequently been confirmed,2 and a dose-response relationship for ischemic heart disease based on individual patient information has been developed.3
Taylor C, Darby SC. Ischemic Heart Disease and Breast Cancer RadiotherapyThe Way Forward. JAMA Intern Med. 2014;174(1):160-161. doi:10.1001/jamainternmed.2013.9131