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The exclusion of older adults, particularly those with complex and multiple chronic conditions, from randomized clinical trials (RCTs) has been well chronicled.1,2 Less well studied is how the preventive benefits seen in participants in RCTs translate to older individuals with multiple chronic health problems.
Tinetti ME. The Gap Between Clinical Trials and the Real WorldExtrapolating Treatment Effects From Younger to Older Adults. JAMA Intern Med. 2014;174(3):397-398. doi:10.1001/jamainternmed.2013.13283