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Invited Commentary
March 2014

The Gap Between Clinical Trials and the Real WorldExtrapolating Treatment Effects From Younger to Older Adults

Author Affiliations
  • 1Section of Geriatrics, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut
  • 2Yale School of Public Health, New Haven, Connecticut
JAMA Intern Med. 2014;174(3):397-398. doi:10.1001/jamainternmed.2013.13283

The exclusion of older adults, particularly those with complex and multiple chronic conditions, from randomized clinical trials (RCTs) has been well chronicled.1,2 Less well studied is how the preventive benefits seen in participants in RCTs translate to older individuals with multiple chronic health problems.

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