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Comment & Response
February 2014

Statins and Musculoskeletal Adverse Events—Reply

Author Affiliations
  • 1VA North Texas Health Care System, University of Texas Southwestern Medical Center, Dallas
  • 2Department of Internal Medicine and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas
  • 3College of Pharmacy, The University of Texas at Austin, Austin
  • 4Pharmacotherapy Education and Research Center, School of Medicine, University of Texas Health Science Center, San Antonio
JAMA Intern Med. 2014;174(2):303-304. doi:10.1001/jamainternmed.2013.12683

In Reply Dr Finkelstein argues that the increase in odds ratios (ORs) of musculoskeletal diseases in statin users may be attributable to imperfect propensity score matching. In addition to the propensity score–matched cohort, we examined the risk of outcomes in different cohorts (Table 2 of our article)1 including a whole population cohort, a no-comorbidity index cohort, a musculoskeletal incident cohort, and a 2-year statin cohort. Each of these cohorts included different populations who varied in baseline characteristics. We also used different definitions for musculoskeletal outcomes. Our results remained consistent throughout.

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