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Comment & Response
March 2014

Mortality and Timing of Surgery for Prosthetic Valve Endocarditis

Author Affiliations
  • 1Division of Infectious Diseases, Department of Medicine, University of California, San Francisco
JAMA Intern Med. 2014;174(3):480. doi:10.1001/jamainternmed.2013.13689

To the Editor We read with interest the recent large prospective cohort study published by Lalani and colleagues1 that evaluated outcomes associated with early surgery vs medical therapy for prosthetic valve endocarditis (PVE).After adjusting for selection and survival bias, no mortality benefit was observed with early surgery. We encourage researchers and especially clinicians to interpret this finding with caution.

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