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Comment & Response
April 2014

What Constitutes an Adequate Evaluation of Device-Guided Breathing?

Author Affiliations
  • 1Department of Medicine, University of California, San Francisco
  • 2Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco
JAMA Intern Med. 2014;174(4):637. doi:10.1001/jamainternmed.2013.13791

To the Editor We were surprised that Landman et al1 felt able to draw strong conclusions about the nonefficacy of device-guided breathing for treatment of hypertension based on a methodologically limited study. Conclusions about nonefficacy should only be drawn from negative results when a trial is adequately powered to determine treatment effects. The authors’ study was small (with only 48 participants) and was underpowered based on wide confidence intervals around estimates of blood pressure.

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