In Reply We want to thank Huang and Subak for their interest in our study.1 They state that we should not have made strong conclusions concerning nonefficacy based on results extending outside the present study and that we performed an underpowered study with methodological limitations and unsuccessful randomization. We respectfully disagree with all their statements.
Landman GWD, van Hateren KJJ, Kleefstra N. What Constitutes an Adequate Evaluation of Device-Guided Breathing?—Reply. JAMA Intern Med. 2014;174(4):638. doi:10.1001/jamainternmed.2013.13790