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In May 2013, Angelina Jolie,1 the actress and director, announced in an op-ed in the New York Times that she carried a BRCA1 mutation and had had a preventive double mastectomy. Jolie’s message was striking—by identifying a mutation in a cancer susceptibility gene, one of the most famous actresses of our generation dramatically reduced her risk of dying from cancer.
McCarthy AM, Armstrong K. The Role of Testing for BRCA1 and BRCA2 Mutations in Cancer Prevention. JAMA Intern Med. 2014;174(7):1023-1024. doi:10.1001/jamainternmed.2014.1322