A man in his 70s with a history of rheumatoid arthritis being treated with infliximab presented to his primary care physician (PCP) with upper respiratory tract congestion of several days’ duration. He was diagnosed as having acute rhinosinusitis and treated with cefdinir. Two days later, he developed diarrhea. After 24 hours of severe diarrhea, he discontinued taking the antibiotic, and the following day his physician prescribed the combination drug diphenoxylate hydrochloride/atropine sulfate (Lomotil; Pfizer Inc).
MacKenzie A. Balancing the Benefits and Risks of Empirical Antibiotics for SinusitisA Teachable Moment. JAMA Intern Med. 2014;174(8):1221-1222. doi:10.1001/jamainternmed.2014.2124