Older adults experience adverse drug events (ADEs) far more often than younger persons. The reasons for this include age-related decline in kidney and liver function, comorbidities, and the use of multiple medications. Oral glucose-lowering agents and insulin are implicated in one-quarter of emergency hospitalizations for ADEs among older US adults.1 Nearly all of these diabetes mellitus (DM)-related drug events are for hypoglycemia. Among oral agents, sulfonylureas lead to most hospital visits for hypoglycemia.
Lipska KJ. Improving Safety of Diabetes Mellitus Management. JAMA Intern Med. 2014;174(10):1612-1613. doi:10.1001/jamainternmed.2014.3290