In response to Krulewitz' comments: Doxycycline is well described to cause photosensitivity reactions.1,2 Although several literature sources report a low incidence of this adverse effect, to our knowledge careful direct comparisons between conventional tetracyclines and doxycycline are not available. The package insert of doxycycline preparations continues to warn of photosensitivity as a potential adverse effect of tetracyclines as a class. In the absence of more concrete data proving otherwise, we believe that this concern should hold for any tetracycline, including doxycycline.
Joshi N, Miller DQ. Rash Decisions—Reply. Arch Intern Med. 1998;158(2):191. doi: