We report a case of an anticonvulsant hypersensitivity syndrome in a 55-year-old white man who presented with a pruritic maculopapular rash, fever, hepatitis, and eosinophilia (13%). The episode was complicated by anterior uveitis, a feature until now not recognized as a manifestation of hypersensitivity to the use of anticonvulsants. He suffered from recent onset of a complex partial seizure with secondary generalization. After neurologic workup, the patient began treatment with carbamazepine. He was healthy until 7 weeks after the start of treatment, when he developed an itching rash of the lower extremities. The treatment was changed to valproic acid.
Ciernik IF, Thiel M, Widmer U. Anterior Uveitis and the Anticonvulsant Hypersensitivity Syndrome. Arch Intern Med. 1998;158(2):192. doi: