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Editor's Correspondence
January 26, 1998

Anterior Uveitis and the Anticonvulsant Hypersensitivity Syndrome

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Intern Med. 1998;158(2):192. doi:

We report a case of an anticonvulsant hypersensitivity syndrome in a 55-year-old white man who presented with a pruritic maculopapular rash, fever, hepatitis, and eosinophilia (13%). The episode was complicated by anterior uveitis, a feature until now not recognized as a manifestation of hypersensitivity to the use of anticonvulsants. He suffered from recent onset of a complex partial seizure with secondary generalization. After neurologic workup, the patient began treatment with carbamazepine. He was healthy until 7 weeks after the start of treatment, when he developed an itching rash of the lower extremities. The treatment was changed to valproic acid.

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