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Editor's Correspondence
January 26, 1998

Tuberculosis-Associated Hemophagocytic Syndrome in Patients With Acquired Immunodeficiency Syndrome

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Intern Med. 1998;158(2):194-195. doi:

Hemophagocytic syndrome (HPS) is an infrequent disorder characterized by a benign proliferation of mature histiocytes and uncontrolled phagocytosis of some hematic precursors in the bone marrow. From a clinical point of view, most of the manifestations can be attributed to pancytopenia.1,2 Hemophagocytic syndrome has been associated with various stimuli, such as infections, malignant neoplasms, and several other immunosuppressive states.1,2 Human immunodeficiency virus (HIV) infection predisposes to the development of infections and hematologic malignancies and thus to reactive bone marrow phenomena, such as HPS.3,4 Among infection-associated HPS, Mycobacterium tuberculosis infection has been described as a severe but not infrequent cause. We recently cared for a patient with acquired immunodeficiency syndrome (AIDS) who presented with tuberculosis-associated HPS, and we reviewed the literature on this topic.

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