The recent article by Piazza et al1 on sexual transmission of the hepatitis C virus (HCV) and efficacy of prophylaxis with intramuscular immune serum globulins (IGs) interested us greatly. The results obtained from this controlled trial showed that HCV can be sexually transmitted by chronically infected patients and provided strong evidence of a protective role of IG produced from unscreened plasma.
Cristiano K, Pisani G, Wirz M, Pini C, Gentili G. More Evidence on Safety of Intramuscular Immune Serum Globulin Produced From Plasma Unscreened for Anti–Hepatitis C Virus Antibodies. Arch Intern Med. 1998;158(7):807–808. doi: