After her daughter died, depression developed in a 93-year-old woman with congestive heart failure receiving digoxin therapy. After treatment with fluoxetine hydrochloride she became anorexic and her serum digoxin level increased. A possible interaction, which has not been reported in the literature, may have occurred between fluoxetine and digoxin.
Leibovitz A, Bilchinsky T, Gil I, Habot B. Elevated Serum Digoxin Level Associated With Coadministered Fluoxetine. Arch Intern Med. 1998;158(10):1152-1153. doi:10.1001/archinte.158.10.1152