We describe a human immunodeficiency virus–seronegative man who presented with a skin disorder that we diagnosed as acute generalized exanthematous pustulosis, which we believe was an adverse reaction to combination prophylactic therapy with zidovudine, lamivudine, and protease inhibitor for human immunodeficiency virus. Cutaneous adverse effects are rarely reported with the use of these antiviral drugs.
Aquilina C, Viraben R, Roueire A. Acute Generalized Exanthematous PustulosisA Cutaneous Adverse Effect Due to Prophylactic Antiviral Therapy With Protease Inhibitor. Arch Intern Med. 1998;158(19):2160-2161. doi:10.1001/archinte.158.19.2160