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Editor's Correspondence
January 14, 2002

Methylmalonic Acid and Clinical Practice

Author Affiliations

Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002

Arch Intern Med. 2002;162(1):102-103. doi:

We read with much interest the article published by Hvas et al.1 It reaches very interesting conclusions and deserves some careful considerations.

The follow-up study of individuals with slightly increased levels of plasma methylmalonic acid (P-MMA) during a period of up to 3.9 years, with no evidence of clinical manifestations of vitamin B12 deficiency, supports the thesis of its doubtful clinical significance as a marker for vitamin B12 deficiency.2,3

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