We thank Dr Levitt for his letter regarding our recent article.1 Using the same study population and analytical methods, we performed additional analyses to examine the predictive value of the TC to HDL-C (TC:HDL-C) ratio for CVD mortality. We found that there was a strong positive association between the TC:HDL-C ratio and CVD mortality. When analyzed as continuous variables, the TC:HDL-C ratio was a somewhat poorer predictor than non–HDL-C level in men (χ2 = 17.0 and 24.3 for the TC:HDL-C ratio and non–HDL-C level, respectively). In women, the TC:HDL-C ratio was a somewhat better predictor than non–HDL-C level (χ2 = 10.9 and 8.3 for the TC:HDL-C ratio and non–HDL-C level, respectively).
Cui Y, Blumenthal RS, Whiteman MK, Flaws JA. The Advantages of Using Non–HDL-C in the Diagnosis and Treatment of Dyslipidemia—Reply. Arch Intern Med. 2002;162(1):109-110. doi: