[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.204.161.30. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Comments, Opinions, and Brief Case Reports
February 11, 2002

Modified Serum Albumin in the Pathogenesis of Glomerular Diseases: A New Hypothesis

Arch Intern Med. 2002;162(3):356-358. doi:

In 1984 we first reported that human serum albumin (HSA) in its denatured form was present in a large amount, up to 25% in terms of fully denaturated protein, in the serum of patients with chronic renal failure (CRF) and patients with the nephrotic syndrome (NS).1 These results were obtained by studying urea levels in hydrolysates (supernatants) of HSA sampled from patients with CRF or NS.1 A comparison of our findings with the literature led to a concept that changed our understanding of the pathophysiologic mechanisms and the nature of glomerulonephritis (GN).

First Page Preview View Large
First page PDF preview
First page PDF preview
×