Metoclopramide hydrochloride, a dopamine D2–like receptor antagonist, is a well-known prokinetic drug. Extrapyramidal side effects due to metoclopramide are not frequently reported.1,2 Although not widely appreciated in the literature, patients with the acquired immunodeficiency syndrome (AIDS) appear to be more susceptible for extrapyramidal side effects. This is illustrated in 3 patients with AIDS, who presented with acute dystonia due to metoclopramide use, within a period of 8 months.
van der Kleij FGH, de Vries PAM, Stassen PM, Sprenger HG, Gans ROB. Acute Dystonia Due to Metoclopramide: Increased Risk in AIDS. Arch Intern Med. 2002;162(3):358-359. doi: