Dr Bellelli and colleagues demonstrated that the Mini-Mental State Examination scores of 34 nondemented older patients were inversely associated with the variability of 24-hour BP. Daytime systolic BP tended to be 8.1 mm Hg lower in the 11 patients with lower Mini-Mental State Examination scores (22-24) than in those 23 patients with a score of 27 or higher. Moreover, in the former 11 patients, nighttime systolic BP was on average 3.5 mm Hg higher than daytime systolic BP, whereas in the other 23 patients, average daytime and nighttime systolic BPs were compatible with a normal diurnal BP profile.
Birkenhäger WH, Forette F, Seux M, Thijs L, Staessen JA. Increased Blood Pressure Variability May Be Associated With Cognitive Decline in Hypertensive Elderly Subjects With No Dementia—Reply. Arch Intern Med. 2002;162(4):483-484. doi: