In the study of unstable angina by Theroux et al1 in 1993, death or myocardial infarction (MI) occurred in 3.7% of aspirin-treated patients and 0.8% of unfractionated heparin–treated patients (P = .04). Comparing unfractionated heparin and aspirin vs aspirin alone, the rate of death or MI during week 1 was 54% lower with unfractionated heparin therapy (P = .002).
O'Rourke RA. New Approaches to Diagnosis and Management of Unstable Angina and Non–ST Segment Elevation Myocardial Infarction: Controversial Data—Reply. Arch Intern Med. 2002;162(4):485-486. doi: