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Editor's Correspondence
April 8, 2002

Is There Proof That Captopril Causes Proteinuria?—Reply

Arch Intern Med. 2002;162(7):842-843. doi:

In reply

I know Dr Engelman from the early days of clinical trials with captopril; I thank him for his remarks. I will not dispute his experience with captopril and proteinuria; however, to the best of my knowledge, these cases have not been published and therefore cannot be critically evaluated.

My letter1 concerned the listing of captopril as a "major" cause of nephrotic syndrome in the otherwise superb review by Madaio and Harrington.2 I asked Dr Madaio if he had new information bearing on this issue; he did not. I therefore pointed out that captopril was by no means a major cause of nephrotic syndrome. I then questioned whether it was ever a cause at all. It is this latter statement that troubles Dr Engelman.

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