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Editor's Correspondence
April 8, 2002

Is Erythema Multiforme Associated With Bupropion Use?

Arch Intern Med. 2002;162(7):843. doi:

Diagnosing dermatological disorders may be difficult, and subtle differences in their clinical features require a specific diagnostic competence to avoid incorrect interpretations. We do not agree with the diagnosis in a case that was reported by Carrillo-Jimenez et al1 in the June 25, 2001, issue of the ARCHIVES.

The patient involved had a hyperacute rash with fever, asthenia, sore throat, chills, and polyarthralgia that had developed after 2½ weeks of bupropion treatment. The skin lesions had a figurate appearance and were fiery red. Laboratory tests revealed only leukocytosis (white blood cell count, 14.3 × 103/µL) with 91% neutrophils. Intravenous methylprednisolone therapy cleared the lesions in 24 hours. The diagnosis was erythema multiforme due to bupropion use.

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