We thank Drs Cainelli and Vento for their interest in our study. They question the necessity of suppressing HIV RNA in plasma to below 5000 to 11 000 copies/mL during antiretroviral therapy to prevent the development of viral resistance and disease progression among asymptomatic HIV-1–infected patients with reasonably maintained CD4 cell counts. Consequently, they also question the necessity of full adherence to HAART in these patients, since this is required for viral suppression.
Nieuwkerk PT, Lange JMA. Full Adherence to HAART: Is It Really Necessary?—Reply. Arch Intern Med. 2002;162(8):945. doi: