We have read the letter from Drs Caserta and Riegler concerning our study on the prevalence of gallstone disease in patients with CD, and would like to make some comments.
First, our study population included only patients with histologically proven CD and would therefore only consider these and not the wider group of patients with IBD. Of the 167 patients with CD previously described in an extensive article by Riegler et al,1 19 (11.5%) had gallstone disease, a strikingly different frequency from the 78 (24%) of 330 patients in our study. It would be of great interest to know the age distribution by sex of the patients from Naples because, given that the mean age of their patients was similar to that of ours (38 ± 15 vs 41 ± 14 years), one possible explanation for the different prevalence of gallstone disease could be a (significantly?) higher proportion of younger patients in their series.
Fraquelli M, Colucci A, Paggi S, Conte D. Hepatobiliary Alterations in Patients With Inflammatory Bowel Disease—Reply. Arch Intern Med. 2002;162(11):1310–1311. doi: