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Clinical Observation
July 22, 2002

Massive Bleeding on a Bladder ProtectantA Case Report of Pentosan Polysulfate Sodium–Induced Coagulopathy

Author Affiliations

From the Department of Medicine, University of British Columbia (Drs Gill and Jamal); and the Division of Clinical Hematology, St Paul's Hospital (Drs Naiman and Vickars), Vancouver, British Columbia.

Arch Intern Med. 2002;162(14):1644-1645. doi:10.1001/archinte.162.14.1644

Pentosan polysulfate sodium (Elmiron; Alza Pharmaceuticals, Mountain View, Calif) is an oral preparation of pentosan polysulfate used in the symptomatic management of interstitial cystitis. While pentosan polysulfate has a known heparinlike effect in its parenteral form, there have been no previous reports of coagulopathy with oral use. We present an interesting case of inadvertent systemic anticoagulation resulting in serious bleeding complications in a young woman taking oral pentosan polysulfate for interstitial cystitis.