We appreciate and welcome the comments of Drs Kashyap. Based on the pathophysiologic and therapeutic principles provided in our review,1 and the series of 6 cases reported by Pichler et al,2 antiandrogen use should be avoided in individuals with hereditary angioedema, particularly when therapeutic alternatives are available. The case report of type II hereditary angioedema in a patient with Turner syndrome3 is the only report of such an association in the English language literature going back to 1966. While noteworthy, we do not consider this compelling evidence for an association between these 2 diseases.
Nzeako UC, Tremaine WJ. Hereditary Angioedema and Hormones—Reply. Arch Intern Med. 2002;162(18):2142. doi: